Background: We aimed to determine the smallest changes in health-related quality of life (HRQoL) scores in the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 and the Brain Cancer Module (QLQ-BN20), which could be considered as clinically meaningful in brain cancer patients. Materials and methods: World Health Organisation performance status (PS) and mini-mental state examination (MMSE) were used as clinical anchors appropriate to related subscales to determine the minimal clinically important differences (MCIDs) in HRQoL (...) change scores (range 0-100) in the QLQ-C30 and QLQ-BN20. A threshold of 0.2 standard deviation (SD) (small effect) was used to exclude anchor-based MCID estimates considered too small to inform interpretation. Results: Based on PS, our findings support the following integer estimates of the MCID for improvement and deterioration, respectively: physical (6, 9), role (14, 12), and cognitive functioning (8, 8); global health status (7, 4(star)), fatigue (12, 9), and motor dysfunction (4(star), 5). Anchoring with MMSE, cognitive functioning MCID estimates for improvement and deterioration were (11, 2(star)) and for communication deficit were (9, 7). Estimates with asterisks were <0.2 SD and were excluded from our MCID range of 5-14. Conclusion: These estimates can help clinicians evaluate changes in HRQoL over time, assess the value of a health care intervention and can be useful in determining sample sizes in designing future clinical trials. (shrink)

Chervenak and McCullough, authors of the most acknowledged ethical framework for maternal–fetal surgery, rely on the ‘ethical–obstetrical’ concept of the fetus as a patient in order to determine what is morally owed to fetuses by both physicians and the women who gestate them in the context of prenatal surgery. In this article, we reconstruct the argumentative structure of their framework and present an internal criticism. First, we analyse the justificatory arguments put forward by the authors regarding the moral status of (...) the fetus qua patient. Second, we discuss the internal coherence and consistency of the moral obligations those authors derive from that concept. We claim that some of the dilemmas their approach is purported to avoid, such as the debate about the independent moral status of the fetus, and the foundation of the moral obligations of pregnant women (towards the fetuses they gestate) are not, all things considered, avoided. Chervenak and McCullough construct the obligations of physicians as obligations towards entities with equal moral status. But, at the same time, they assume that the woman has an independent moral status while the moral status of the fetus is dependent on the decision of the woman to present it to a physician for care. According to the logic of their own argumentation, Chervenak and McCullough implicitly admit a different moral status of the woman and the fetus, which will lead to different ascription of duties of the physician than those they ascribed. (shrink)

In the present paper I investigate the role that analogy plays in eighteenth-century biology and in Kant’s philosophy of biology. I will argue that according to Kant, biology, as it was practiced in the eighteenth century, is fundamentally based on analogical reflection. However, precisely because biology is based on analogical reflection, biology cannot be a proper science. I provide two arguments for this interpretation. First, I argue that although analogical reflection is, according to Kant, necessary to comprehend the nature of (...) organisms, it is also necessarily insufficient to fully comprehend the nature of organisms. The upshot of this argument is that for Kant our understanding of organisms is necessarily limited. Second, I argue that Kant did not take biology to be a proper science because biology was based on analogical arguments. I show that Kant stemmed from a philosophical tradition that did not assign analogical arguments an important justificatory role in natural science. Analogy, according to this conception, does not provide us with apodictically certain cognition. Hence, sciences based on analogical arguments cannot constitute proper sciences. (shrink)

We highlight a recent study exploring the hand‐off of UV damage to several key nucleotide excision repair (NER) proteins in the cascade: UV‐DDB, XPC and TFIIH. The delicate dance of DNA repair proteins is choreographed by the dynamic hand‐off of DNA damage from one recognition complex to another damage verification protein or set of proteins. These DNA transactions on chromatin are strictly chaperoned by post‐translational modifications (PTM). This new study examines the role that ubiquitylation and subsequent DDB2 degradation has during (...) this process. In total, this study suggests an intricate cellular timer mechanism that under normal conditions DDB2 helps recruit and ubiquitylate XPC, stabilizing XPC at damaged sites. If DDB2 persists at damaged sites too long, it is turned over by auto‐ubiquitylation and removed from DNA by the action of VCP/p97 for degradation in the 26S proteosome. (shrink)

In this interview with Jan Hendrik van den Berg, the Dutch phenomenologist and psychiatrist addresses the origins of his work, his most significant influences, and the purpose of metabletic phenomenology in the modern age. In the course of the interview. Dr. Van den Berg provides a basic overview of his work, and highlights the central finding of his metabletic analyses: a loss of wonder before nature, which results from the more fundamental loss of genuine spirituality in the modern world.

Background: Empirical studies in Muslim communities on organ donation and blood transfusion show that Muslim counsellors play an important role in the decision process. Despite the emerging importance of online English Sunni fatwas, these fatwas on organ donation and blood transfusion have hardly been studied, thus creating a gap in our knowledge of contemporary Islamic views on the subject.Method: We analysed 70 English Sunni e-fatwas and subjected them to an in-depth text analysis in order to reveal the key concepts in (...) the Islamic ethical framework regarding organ donation and blood transfusion.Results: All 70 fatwas allow for organ donation and blood transfusion. Autotransplantation is no problem at all if done for medical reasons. Allotransplantation, both from a living and a dead donor, appears to be possible though only in quite restricted ways. Xenotransplantation is less often mentioned but can be allowed in case of necessity. Transplantation in general is seen as an ongoing form of charity. Nearly half of the fatwas allowing blood transfusion do so without mentioning any restriction or problem whatsoever. The other half of the fatwas on transfusion contain the same conditional approval as found in the arguments pro organ transplantation.Conclusion: Our findings are very much in line with the international literature on the subject. We found two new elements: debates on the definition of the moment of death are hardly mentioned in the English Sunni fatwas and organ donation and blood transfusion are presented as an ongoing form of charity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BreathingLuk Van den Dries (bio)This text, "Breathing," was conceived for the book From Act to Acting: Fabre's Guidelines for the Performer of the 21st Century (2021). The book was conceived and designed by Jan Fabre, author, theatre artist, and visual artist, active since the 1970s. The book was written by Luk Van den Dries, dramaturg and theatre researcher of the University of Antwerp, in tight collaboration with Jan Fabre (...) and the three most important performers/teachers of the Belgian theatre company, Troubleyn (Annabelle Chambon, Cédric Charron, and Ivana Jozic). The book sheds new light on the physical, mental, and vocal training of the performer and furthermore gives insight into Fabre's revolutionary thoughts on contemporary theatre.1Breathing is the first of the ten performative principles that together create the basic grammar in which the language of the performers is grounded.Three-phased breathing (one part in, one part out, one part nothing) is a basic condition in the series of exercises Jan Fabre developed throughout his career. This respiration technique returns in all exercises. Also, it is the first principle that the performers are taught: by dividing breathing into three equal parts, energy is built up and stress or fatigue is canalized. It is a way to rebalance, to find a place of rest after a strenuous effort, or it can also be used as a springboard to a heightened performance. Very regularly during individual exercises, Fabre will refer to this respiration technique, especially in specific situations of high adrenaline, but of course the performers should learn to use this respiration technique autonomously. They should become so familiar with the rhythm of this breathing that they automatically fall back on it when necessary. Because this respiration technique is so crucial to Fabre's acting pedagogy, it is described in detail as the very first exercise in his book. Its basic principles are explained below as well, as the first performative principle.Breathing is a sign of life, and on this primal and essential level it needs to be understood that, through breathing, the performer gives life. He breathes life into the performance. Fabre himself has described this basic condition for the birth of theatre through breathing very precisely: [End Page 30]The most important weapon of the warrior of beauty is his respiration. When the performance starts, life stops. Life itself dies. The warrior of beauty is alive, but life itself is dead. The warrior of beauty remains with just his own breath. When he enters the stage, he needs to breathe life into deceased life. Like a god gives his breath to create life. In the same way he will create life with his breath. How will he achieve this? By breathing correctly: one-third inhaling through the nostrils, one-third exhaling through pursed lips, one-third without breathing. And then the miracle happens. The breath becomes imagination and the imagination breathes. The warrior of beauty is the master of breath and life.2Fabre's abdominal breathing differs from regular forms of breathing, such as techniques derived from Asian yoga techniques, Chi-kung or Tai-chi, as it stresses different parts. At the same time, it is closely related to it, because these practices also adopt the notion that breathing in the first place rouses vitality and spirit and that the right kind of breathing thus aims at controlling life currents and bringing about a clear mind. In yoga it is called pranayama: prana meaning spirit or force of life, ayama meaning 'control' or 'grasp.' Yoga knows many variants in directing the breath, depending on the asanas (yoga postures) in which they are bedded. Sometimes focusing mainly on the diaphragm and the flanks, sometimes on abdominal breathing. Also, suspending your breath (kumbhaka) is a yoga technique, applied at the end of inhalation as well as after exhalation and during taking breath.In Fabre's case, abdominal breathing is stressed: first, air is inhaled through the nose, subsequently sent in the direction of the peritoneal cavity and the flanks, and then again exhaled via a very precise blowing technique (a dosed flow of air through an imaginary straw). During the cycle the diaphragm remains... (shrink)

The present article puts forward a behavioral disinhibition hypothesis stating that, often, at least some levels of behavioral disinhibition are needed to overcome people’s inhibition to intervene in dilemmatic situations in which they have to choose between different actions with good reasons for each of the actions involved. Results reported indeed show that people to whom disinhibited behaviors were salient or people with stronger predispositions toward behavioral disinhibition were more likely to intervene in trolley and footbridge dilemmas.

This essay takes Arthur Danto’s end-of-art thesis as a case in point of a substantive philosophy of history. Such philosophy explains the direction that art has taken and why that direction could not have been different. Danto never scrutinized the philosophy of history that his end-of-art thesis presumes. I aim to do that by drawing a distinction between what I refer to as the common view of history and the philosophical view of history, and by arguing that we need the (...) latter if we want to properly assess the plausibility of the end-of-art thesis. (shrink)

Knowledge about the ‘other’ is one of the founding pillars for the development of global political theory. Although human rights are an important part of the moral and legal discourse on global governance, there is still a gap between these theories and detailed accounts of human rights violations and the context for resistance. This article examines the treatment of the ‘other’ in a specific country (Iran), and the oppression as Muslims of Iranians living abroad, in order to begin to fill (...) this gap. More specifically, it is argued that anthropology, journalism and diaspora literature about Iran provide useful input for the field of global political theory on human rights, democratisation and global justice. This literature helps bring home the realities of human rights violations, contributes to a better understanding of injustice and ways of creating social change, and illuminates issues of universality and difference that are of direct relevance to global political theory. (shrink)

In response to the phenomenon of women converting to Islam, a body of research has emerged, engaging with the question, ‘Why are Western women, raised in liberal contexts, converting to Islam?’ This line of enquiry is not limited to academic literature. In recent years, converts to Islam have faced intense scrutiny in mainstream media across Europe. This article contributes an analysis of documentaries to the study of representations of female converts to Islam, focusing particularly on the British documentary Make Me (...) a Muslim and the Swiss documentary Les Converties d’Allah. We suggest that comparing these two documentaries illuminates certain common narrative threads in media representations of female converts to Islam across different European contexts. In this article, we firstly situate this research within existing literature on gender and conversion to Islam and outline our approach to the study of documentaries on women’s conversion to Islam. Secondly, we analyse the two documentaries, focusing on their shared concerns, namely gender equality and women’s oppression, and the familial environment of the female convert. We argue that paying attention to how female converts are represented illuminates some of the ways in which European framings of the ‘in-betweenness’ of female converts to Islam create notions of female converts as ‘vulnerable-fanatics’ prone to ‘radicalisation’, and threatened by ‘oppressive’ Islam. We demonstrate how female converts participating in documentaries at times complicate and talk back to apprehensions regarding equality, oppression and radicalisation. Finally, we focus in a similar way on understandings of female converts as ‘troublemakers’ within their family environments. Throughout the analysis, we show how the figure of the female convert as vulnerable-fanatic and as family troublemaker is gendered and interlaced with concerns about essentialised cultural difference and radicalisation. (shrink)

Social media makes an important contribution to a rapidly changing world in which various domains of meaning are described anew. The evolving nature and dynamic character of social media therefore provides for a rich praxis terrain with which to interact from a practical theological orientation. More specifically associated with the theme of this contribution, the social media sphere also provides an excellent space not only to rethink but also to reenact expressions of dignity in society. The research is facilitated from (...) a practical theological orientation, with particular focus on a normative dimension as embodied in aspects of dignity. Through the use of an interdisciplinary approach and methodology, some contours of dignity specifically associated with South African politics as well as the so-called Charlie Hebdo attacks in 2015 in Paris expressed on the social media platform, Twitter, are described and discussed. From this empirical analysis, description and discussion, a practical theological reflection is offered in which aspects of dignity associated with a normativity function are described. Some practical theological perspectives contributing to future relevant tweeting on dignity are also formulated and provided in conclusion. (shrink)

This article constitutes the introduction to a collection of essays in volume 4 of JAE, representing an extremely diverse collection of pieces written by authors from equally diverse backgrounds with the purpose of sharing the theoretical and practical issues related to research-ethics, or on ethics more generally. All of the articles are fresh contributions to the research-ethics review debate. The 17 authors of the 12 articles come from the United States, South Africa, and Canada. Their disciplinary or research backgrounds include (...) Aboriginal literatures, English literature, English-as-a Second-Language pedagogy, French literature, history, language and literacy, liberal arts, and linguistics – all fields in the cluster of the humanities. The volume also has contributions from social work, sociology, and speech pathology. The world of research-ethics review has become so pervasive that it invades all areas of research: it does not respect disciplinary boundaries. The articles in this special volume represent, in short, a microscope of the research world. (shrink)

The main object of this study is to find out whether the differences between classical and medieval thinking about work, occupations and technology are so significant that we are justified in speaking of a real break between Antiquity and the Middle Ages in this connection; or whether there is a possible continuity of ideas. From a comparative perspective five themes are being researched to shed light on this ques-tion. In the first two chapters the author looks into the traditional view (...) of negative ideas about work in Antiquity. Chapter three subsequently deals with monks and their attitude towards labour. In chapter four the place of the so-called artes mechanicae in medieval classifications of knowledge is being studied. In chapter five we find an analysis of twelfth-century sermons ad status. These three chapters principally deal with the question whether Christianity brought about a change in attitude towards work. (shrink)

Much clinical and ethnographic evidence suggests that humans, like many other organisms, are selected to avoid close inbreeding because of the fitness costs of inbreeding depression. The proximate mechanism of human inbreeding avoidance seems to be precultural, and to involve the interaction of genetic predispositions and environmental conditions. As first suggested by E. Westermarck, and supported by evidence from Israeli kibbutzim, Chinese sim-pua marriage, and much convergent ethnographic and clinical evidence, humans negatively imprint on intimate associates during a critical period (...) of early childhood.There is also much evidence that, like other social animals, humans do not seek to maximize outbreeding, but rather to maintain an optimal balance between outbreeding and inbreeding.Closeinbreeding reduces fitness through inbreeding depression, butsomeinbreeding brings the benefits of nepotism. For simple, stateless, horticultural societies, the optimal balance seems to be achieved by a combination of precultural inbreeding avoidance of relatives with anr≤·25 and cultural rules of preferential marriage with kin withr≥·25. Adjustment of the coefficient of inbreeding to other ecological settings seems to be largely cultural. An interactive model of “culture in nature” is presented, in which culture is seen as coevolving with genes to produce the maxiniization of individual inclusive fitness. (shrink)

Este artículo sostiene que Platón constituye un interlocutor fructífero para la Teoría crítica. Desde un diálogo con Axel Honneth, argumentaremos primero que la metodología de crítica social desarrollada en la República posee elementos constructivo-racionales y reconstructivo-hermenéuticos. Luego, enfatizaremos dos conceptos prefigurados en dicha obra que, mediante Hegel, yacen en el trasfondo de la Teoría crítica, a saber: holismo y patología social. Ello nos permitirá articular, como conclusión, una “dialéctica de la justicia” que, en el sentido de Adorno & Horkheimer, recorre (...) la obra de Honneth. (shrink)

Let T be a complete o-minimal extension of the theory of real closed fields. We characterize the convex hulls of elementary substructures of models of T and show that the residue field of such a convex hull has a natural expansion to a model of T. We give a quantifier elimination relative to T for the theory of pairs (R, V) where $\mathscr{R} \models T$ and V ≠ R is the convex hull of an elementary substructure of R. We deduce (...) that the theory of such pairs is complete and weakly o-minimal. We also give a quantifier elimination relative to T for the theory of pairs (R, N) with R a model of T and N a proper elementary substructure that is Dedekind complete in R. We deduce that the theory of such "tame" pairs is complete. (shrink)

* The editorial board wishes to thank Hildegard Penn of Tilburg University for her meticulous editorial work on this issue.

Review of Joke J. Hermsen. 2022. A Good & Dignified Life: The Political Advice of Hannah Arendt & Rosa Luxemburg (translated from the Dutch by Brendan Monaghan). New Haven & London: Yale University Press.